• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Disclosed is a process for increasing the proportion of a desired enantiomer of a 2-arylpropionic acid which comprises heating at a temperature of at least 80.degree.C a mixture comprising an inert liquid organic diluent and a salt of the 2-arylpropionic acid with an enantiomer of a chiral organic nitrogenous base, the base and the diluent being such that the salt of the racemic acid has a solubility of 0.1 to 10% w/v in the diluent at the operating temperature and in whidh process a proportion of the salt is undissolved in the diluent, whereby a proportion of one optical isomer of the acid component of the salt is converted into its enantiomer, and collecting the salt of which the acid component has an increased proportion of that enantiomer.
    公开号:SU784759A3
    申请号:SU782588501
    申请日:1978-03-07
    公开日:1980-11-30
    发明作者:Стюарт Никольсон Джон；Гордон Тантум Джеймс
    申请人:Дзе Бутс Компани Лимитед (Фирма)；
    IPC主号:
    专利说明:

    one or more organic compounds. At the end of the heating, the hot mixtures are filtered through a Buchner funnel, the salts are washed with a hot diluent, dried under vacuum, acidified with dilute sulfuric or hydrochloric acid, and the acid mixtures are extracted with ether.
    The ether extracts are washed with water, dried and evaporated to form 2-aryl-propionic acids, which have different optical activity, from the acid component of the salt at the beginning of the experiment.
    Details and results of various examples are given in table. one.,
    Continued table.
    权利要求:
    Claims (1)
    [1]
    <claim-text> <table border = "1"><tbody> <tr> <td>11 - </ td> <td>(+) </ td> <td>-cC- (2-methoxyphenyl) -ethyl - </ td> </ tr><tr> <td colspan = "3">Amin. </ td> </ tr><tr> <td>12 </ td> <td>(-) </ td> <td>(2-methoxyphenyl) -ethyl - </ td> </ tr><tr> <td colspan = "3">Amin. </ td> </ tr><tr> <td>m - </ td> <td>(-) </ td> <td>-sb- (4-fluorophenyl) -ethylamine. </ td> </ tr><tr> <td>N '- </ td> <td>(4) </ td> <td>"about" (2-fluorophenyl) -ethylamine. </ td> </ tr><tr> <td>0 - </ td> <td>(-) </ td> <td>- “£ - (2-chlorophenyl) -ethylamine. </ Td> </ tr><tr> <td>P - </ td> <td>(-) </ td> <td>-oCg (3-fluorophenyl) -ethylamine. Solvents </ td> </ tr></ tbody> </ table><claim-text> K - Oil fraction, interval t. Kip. 112-130 ° C, (-) -oC-pinene. </ Claim-text><claim-text> T - myrcene. </ claim-text><claim-text> 81 - 85% K + 15% toluene, and 2 - 67% "+ 33% toluene. </ claim-text><claim-text> V - Oil fraction, interval </ claim-text><claim-text> ft. 120-160 C. </ claim-text><claim-text> Y - Oil fraction, interval </ claim-text><claim-text> ft. 125-160 ° C. </ Claim-text><claim-text> X - Octane. </ claim-text>
    类似技术:
    公开号 | 公开日 | 专利标题
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    同族专利:
    公开号 | 公开日
    ES467606A1|1978-10-16|
    NL189126C|1993-01-18|
    IT7848320D0|1978-03-07|
    LU79186A1|1978-09-18|
    PT67743A|1978-04-01|
    HU178810B|1982-06-28|
    GR64816B|1980-06-03|
    IN147834B|1980-07-19|
    JPS626536B2|1987-02-12|
    NO146197B|1982-05-10|
    DD136261A5|1979-06-27|
    CH638482A5|1983-09-30|
    PL110888B1|1980-08-30|
    IE46476B1|1983-06-29|
    IT1202818B|1989-02-09|
    DK154418B|1988-11-14|
    JPS53112841A|1978-10-02|
    FI780738A|1978-09-09|
    CS222255B2|1983-06-24|
    FI66828C|1984-12-10|
    AT360508B|1981-01-12|
    PH13333A|1980-03-13|
    AU521708B2|1982-04-29|
    EG13345A|1981-06-30|
    NZ186644A|1980-10-24|
    SE436422B|1984-12-10|
    YU54078A|1984-04-30|
    ATA163478A|1980-06-15|
    NL189126B|1992-08-17|
    NL7802520A|1978-09-12|
    CA1105942A|1981-07-28|
    DE2809794A1|1978-09-21|
    DK100878A|1978-09-09|
    PL205161A1|1979-03-26|
    FR2383155B1|1983-12-30|
    DK154418C|1989-06-19|
    AU3397778A|1979-09-13|
    NO146197C|1982-08-18|
    NO780785L|1978-09-11|
    YU41472B|1987-08-31|
    FR2383155A1|1978-10-06|
    DE2809794C2|1989-08-03|
    SE7802603L|1978-09-09|
    BG28567A3|1980-05-15|
    FI66828B|1984-08-31|
    IE780467L|1978-09-08|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    IL23268A|1964-05-07|1969-02-27|Merck & Co Inc|Anti-inflammatory compositions containing 4-phenyl-alpha-methyl-phenylacetic acid|
    FR2015728B1|1968-04-18|1973-07-13|Lilly Co Eli|
    US3686183A|1969-03-24|1972-08-22|Syntex Corp|Preparation of optical isomers of arylalkylacetic acids|DE2826952A1|1978-06-20|1980-01-10|Bayer Ag|ENANTIOMER SEPARATION OF CHIRAL CARBONIC ACIDS|
    PH15674A|1979-07-06|1983-03-11|Syntex Corp|Process for the resolution of d,1 2-propionic acid|
    JPS6321654B2|1981-03-06|1988-05-09|Hiroyuki Nohira|
    JPH01126425U|1988-02-23|1989-08-29|
    DE3824353A1|1988-07-19|1990-01-25|Paz Arzneimittelentwicklung|METHOD FOR SEPARATING MIXED ENANTIOMER ARYLPROPIONIC ACIDS|
    DE4028906C2|1990-09-12|1992-10-29|Paz Arzneimittelentwicklung|
    DE4319438C1|1993-06-11|1994-06-01|Gerd Dr Dr Geislinger|Analgesic and/or antiinflammatory medicaments - contg. sepd enantiomers of ketoprofen|
    JP3782834B2|1994-10-26|2006-06-07|株式会社トクホン|Analgesic anti-inflammatory patch|
    DE19717429A1|1997-04-25|1998-12-24|Bayer Ag|Production of enantiomerically pure biaryl ketocarboxylic acids|
    CN102388014A|2009-02-06|2012-03-21|帝斯曼知识产权资产管理有限公司|Method for the synthesis of chiral alpha-aryl propionic acid derivatives|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    GB9697/77A|GB1596032A|1977-03-08|1977-03-08|Resolution of optically active 2-arylpropionic acids|
    GB194678|1978-01-18|
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